Trypanosomes – Diagram, Morphology and Life Cycle

Trypanosoma is a genus of unicellular parasites responsible for diseases like African trypanosomiasis and Chagas disease. These parasites exhibit a distinctive morphology, featuring a long, undulating membrane and a flagellum for motility.

The cell body is elongated with a single nucleus and a kinetoplast containing mitochondrial DNA. Trypanosoma’s life cycle involves transmission through insect vectors, which affect human and animal health in various regions. In this article, we will learn about the morphology and life cycle of the Trypanosoma in detail.

What is Trypanosoma?

The word “Trypanosoma” originates from the Greek words “trypano” and “soma” which means borer and body. Trypanosoma is a parasitic protozoa which belongs to the class Kinetoplastida. These single-celled organisms are flagellated and typically found in the bloodstream of vertebrates, including mammals, birds, and reptiles. There are various species of Trypanosoma, some of which are harmless, while others are responsible for causing diseases in humans and animals.

One of the most well-known species is Trypanosoma brucei, which causes sleeping sickness in humans. This disease is transmitted to humans through the bite of infected tsetse flies. Another important species is Trypanosoma cruzi, which causes Chagas disease in humans and is transmitted by faeces of kissing bugs. Some Trypanosome species require more than one host to complete their life cycle.

Trypanosoma Classification

Below is the detailed biological classification of Trypanosomes.

Domain	Eukaryota
Phylum	Euglenozoa
Class	Kinetoplastea
Order	Trypanosomatida
Family	Trypanosomatidae
Genus	Trypanosoma

Labeled Diagram of Trypanosoma

The diagram of Trypanosoma with label is shown below:

Labeled Diagram of Trypanosoma

Morphology of Trypanosoma

Trypanosoma is a single celled organism with distinct morphological features. Key features includes:

• Size: Trypanosomes measure from 12 to 30 µm in length.
• Body shape: It has a spindle shaped elongated body which somewhat looks like a banana and has tapering ends.
• Undulating Membrane: Trypanosoma features a unique undulating membrane, extending from the posterior end, providing a characteristic appearance.
• Flagellum: It has flagellum which emerges from the anterior part of the cell. It helps in locomotion and movement.
• Kinetoplast: It has kinetoplast which contains genetic material known as kinetoplast DNA (kDNA). It plays role in replication and other genetic processes
• Nucleus: It has single centrally located nucleus which regulates gene expression.
• Trypanosoma exist in two different types and that have different types of life cycles – stercorarian and salivarian species.

Life Cycle of Trypanosoma

The life cycle of Trypanosoma brucei is discussed below:

• The life cycle of Trypanosoma brucei begins when an infected tsetse fly feeds on the blood of a mammalian host, such as a human or animal and introduces infective metacyclic trypomastigotes.
• Once inside the bloodstream, the metacyclic trypomastigotes differentiate into trypomastigotes, which multiply and spread throughout the host’s blood. Trypomastigotes undergo repeated antigen variation and evades the immune system of the host.
• When an uninfected tsetse fly feeds on the blood of an infected mammalian host, it ingests bloodstream trypomastigotes along with the blood meal.
• These trypomastigotes converts into procyclic trypomastigotes in the mid gut of the tse tse fly and differentiate to form epimastigotes that migrate to the salivary gland of the Trypanosoma brucei.
• When this infected tse tse fly bites a healthy human they transmit the pathogent to his blood stream, and complete the life cycle.

Life Cycle of Trypanosoma Diagram

The life cycle of Trypanosoma diagram is given below:

Life Cycle of Trypanosoma Diagram

Trypanosoma: Common species

Two species of the genus Trypanosoma are well-known to cause chronic disease:

Trypanosoma brucei

Trypanosoma brucei gambiense is a parasitic species well known to cause chronic African Trypanosomiasis or sleeping sickness in humans. In animals, it can cause Animal Trypanosomiasis. Sleeping sickness in humans is characterised by headache, itchiness, numbness, and joint pains that gradually progress towards sleeping disorders. The protozoan is transmitted via Tsetse fly bite.

Trypanosoma cruzi

Trypanosoma cruzi rhodisiense causes acute African sleeping sickness, Chagas disease in humans, brucellosis in cows and surra in horses. The disease in humans is characterised by lymph node swelling, headache along with swelling in the insect-bitten area. Severe infection may lead to convulsions, heart failure, and coma followed by death.

Diseases Caused by Trypanosoma

They are responsible for causing several disease in human and animals. Some of the diseases caused by trypanosoma are:

• African Trypanosomiasis (Sleeping Sickness): It is caused by Trpanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which is transmitted to humans by the bite of infected tsetse flies. This is a dangerous disease which leads to chronic symptoms and ultimately death.
• Chagas disease (American Trypanosomiasis): This disease is prevalent in Latin America which is caused by Trypanosma cruzi. It is transmitted through the bite of infected triatomine bugs also known as kissing bugs.
• Surra disease: It is caused by Trpanosoma evansi which affects the mammalian host including horse, horse, and camel.

Disease Prevention

The disease can be prevented by vector control, proper screening and surveillance, education and awareness, and livestock management. Some general measures are discussed as follows:

Vector Control

Insecticide-treated targets, traps, or screens can be deployed in areas with high vector populations to reduce their numbers. Clearing bushes and vegetation, which are preferred habitats for vectors, can also help reduce breeding sites.

Surveillance and Screening

Screening of populations in endemic regions for signs and symptoms of trypanosomiasis can help identify cases early and initiate treatment promptly. Blood tests can also be used to detect the presence of Trypanosoma parasites in humans and animals, even in asymptomatic individuals.

Treatment of Infected Individuals

Prompt treatment with trypanocidal drugs can prevent the progression of the disease to its more severe stages and reduce transmission to others. Ensuring that effective drugs are available and accessible to affected populations is crucial for treatment success.

Community Education and Awareness

Educating communities about the risks of trypanosomiasis, the importance of seeking medical care if symptoms occur, and methods to prevent bites from tsetse flie can help in reducing the outbreak. Encouraging the use of insect repellents, wearing protective clothing (long sleeves, pants), and sleeping under insecticide-treated bed nets in endemic areas.

Livestock Management

Treating infected animals with trypanocidal drugs and implementing measures to reduce tsetse fly exposure, such as using insecticide-treated livestock collars can prevent transmission through animals. Selective breeding of livestock for resistance or tolerance to trypanosome infection can help reduce the impact of the disease on animal health and productivity.

Conclusion: Trypanosoma – Diagram, Morphology

In conclusion, Trypanosoma exhibits a distinctive morphology characterized by an elongated cell body with an undulating membrane and a flagellum for motility. The presence of a single nucleus and a kinetoplast, containing mitochondrial DNA, contributes to its unique appearance. It is capable of causing chronic, African sleeping sickness. The parasite enters the human body through the Tsteste fly bite. It is an obligatory parasite and lives in other invertebrate hosts as well. Trypanosomes have two morphological forms for living in different host bodies.

FAQs on Trypanosoma – Diagram, Morphology

What is Trypanosoma?

Trypanosoma is a unicellular, flagella containing active motile protozoan. These zoonotic obligatory parasites cause African sleeping sickness in humans. They contain genetic information in the form of kinetoplast or kDNA, a thick interlocked form of DNA molecules.

Explain the Morphology of Trypanosoma.

Trypanosomes have spindle-shaped flattened bodies. They have a pointed anterior end and a blunt posterior end with a flagellum arising from the basal body situated closer to the kinetoplast.

What is the Shape of Trypanosoma Under a Microscope?

Trypanosoma are unicellular protozoans, visible only under a microscope. They appear as flat, spindle-shaped bodies with blunt posterior and pointed anterior ends.

Name Some Diseases that Trypanosoma Causes.

T. brucei causes African sleeping sickness that is initially characterised by itchiness, numbness, headache and joint pains. Chronic untreated infection causes sleep disturbances, heart failure, convulsions and coma. T. cruzi can cause Chagas disease in humans and surra in livestock like horses.

Explain the Life Cycle of Trypanosoma.

Trypanosoma is an obligatory parasite and requires more than one host to complete its life cycle. One is the stercorarian form that develops in the posterior gut of the insect. The other is the salivarian form that lives in the anterior gut of an insect.

What is the Shape of Trypanosoma?

Trypanosoma are unicellular protozoans, visible only under a microscope. They appear as flat, spindle-shaped bodies with blunt posterior and pointed anterior ends.

What is Trypanosoma Body Structure ?

Trypanosama has a flattened, elongated and fusiform body which looks like the shape of banana.

What is the Morphology of the Trypomastigote?

Trypomastigotes are protozoan forms found in the life cycle of Trypanosoma cruzi and is responsible for Chagas disease. It has single nucleus, single flagellum and spindle shaped, elongated cells having kinetoplast.

What are the Three Types of Trypanosoma?

Trypanosoma species include T. brucei, T. cruzi, and T. vivax, causing various diseases in humans and animals.

What is the Definition of Trypanosoma in Biology?

In biology, Trypanosoma refers to a genus of parasitic protozoans transmitted by insect vectors

What is Trypanosoma Body Structure?

Trypanosoma has a single cell with a distinct nucleus, flagellum, and kinetoplast, often elongated or spindle-shaped.

What is Trypanosoma brucei Structure and Function?

Trypanosoma brucei possesses a long, slender body with a flagellum, enabling movement and invasion of host cells, causing African sleeping sickness.