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Blood Group System – An Overview

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  • Last Updated : 14 Sep, 2022
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The expression “blood group” alludes to the whole blood group framework containing red platelet (RBC) antigens whose explicitness is constrained by a series of qualities that can be allelic or connected intently on a similar chromosome. “Blood classification” alludes to a particular example of a response to testing antisera inside a given framework. Throughout some stretch of time, our understanding of blood bunches has developed to envelop not just bonding-related issues yet additionally unambiguous sickness relationships with RBC surface antigens. Karl Landsteiner has been credited for the revelation of the ABO blood group framework in 1900. His broad examination of serology in view of basic in any case, solid logical thinking prompted recognizable proof of significant blood gatherings like O, A, and B types, similarity testing, and ensuing bonding rehearses. He was granted Noble Prize in 1930 for this revelation. His tribute records a gigantic commitment of in excess of 346 distributions. Afterward, Jan Jansky portrayed the order of human blood gatherings of four sorts.

Blood Group

As of now, 33 blood group frameworks addressing north of 300 antigens are recorded by the International Society of Blood Transfusion. The greater part of them has been cloned and sequenced. The qualities of these blood group frameworks are autosomal, with the exception of XG and XK which are X-borne, and MIC2 which is available on both X and Y chromosomes. The antigens can be indispensable proteins where polymorphisms lie in the variety of amino corrosive succession (e.g., rhesus [Rh], Kell), glycoproteins, or glycolipids (e.g., ABO).

ABO framework

Among the 33 frameworks, ABO stays the main in bonding and transplantation since any individual over the age of a half year has clinically a huge enemy of An or is potentially hostile to B antibodies in their serum. Blood bunch A contains an immune response against blood bunch B in serum as well as the other way around, while blood bunch O contains no A/B antigen however both their antibodies in serum.


H-antigen is the forerunner to the ABO blood bunch antigens. It is available in all RBCs regardless of the ABO framework. People with the uncommon Bombay aggregate are homozygous for the H quality (HH) and don’t communicate H-antigen on their RBCs. As H-antigen goes about as a forerunner, its nonattendance implies the shortfall of antigens A and B. Be that as it may, the people produce isoantibodies to H-antigen as well as to antigens A and B.

Rhesus framework

Rhesus framework is the second most significant blood bunch framework after ABO. Presently, the Rh framework comprises 50 characterized blood bunch antigens out of which just five are significant. RBC surface of an individual could conceivably have an Rh factor or immunogenic D-antigen. In like manner, the status is shown as either Rh-positive (D-antigen present) or Rh-negative (D-antigen missing). Rather than the ABO framework, hostile to Rh antibodies are, typically, not present in that frame of mind of people with D-pessimistic RBCs, except if the circulatory arrangement of these people has been presented to D-positive RBCs. These safe antibodies are immunoglobulin G (IgG) in nature and subsequently, can cross the placenta. Prophylaxis is given against Rh vaccination involving hostile to D Ig for pregnant Rh-negative moms who have brought forth Rh-positive kids.

MNS antigen framework

MNS antigen framework, first portrayed via Landsteiner and Levine in 1927 depends on two qualities: Glycophorin An and Glycophorin B. The blood bunch is taken care of an autosomal locus on chromosome 4 and furthermore taken care of a couple of co-predominant alleles LM and LN. Hostile to M and against N antibodies are typically IgM types and once in a long while, related to bonding responses.

Lutheran framework

The lutheran framework contained four sets of allelic antigens addressing single amino corrosive replacement in the Lutheran glycoprotein at chromosome 19. Antibodies against this blood bunch are interesting and for the most part not considered clinically huge.

Kell framework

These erythrocyte antigens are the third most powerful immunogenic antigen after ABO and Rh framework and are characterized by a resistant counteracting agent, against K. It was first seen in the serum of Mrs. Kellacher. She responded to the erythrocytes of her baby bringing about hemolytic responses. From that point forward 25 Kell antigens have been found. Against K counter acting agent causes extreme hemolytic illness of the embryo and infant (HDFN) and hemolytic bonding responses (HTR).

Duffy framework

Duffy-antigen was first detached in a patient called Duffy who had hemophilia. It is otherwise called Fy glycoprotein and is available in the outer layer of RBCs. It is a vague receptor for a few chemokines and goes about as a receptor for the human malarial parasite, Plasmodium vivax. Antigens Fya and Fyb on the Duffy glycoprotein can bring about four potential aggregates, in particular Fy(a+b−), Fy(a+b+), Fy(a−b+), and Fy(a−b−). The antibodies are IgG subtypes and can cause HTR.

Kidd framework
Kidd antigen (known as Jk antigen) is a glycoprotein, present on the film of RBCs and goes about as a urea carrier in RBCs and renal endothelial cells. Kidd antibodies are uncommon yet can cause serious bonding responses. These antigens are characterized by responses to a neutralizer assigned as hostile to Jka, found in the serum of Mrs. Kidd who conveyed a child with HDFN. Jka was the principal antigen to be found by the Kidd blood bunch framework, accordingly, two different antigens Jkb and Jk3 were found.

Agarwal et al. completed a concentrate on the mechanized examination of blood bunches in the north Indian giver populace and saw that the normal blood bunches arranged by recurrence were B, O, A, and AB; 94.4% being Rh-positive. In minor blood gatherings, the most ordinarily seeming aggregates were Le (a−b−) for Lewis, Fy(a+b+) for Duffy, Jk(a+b+) for Kidd, and M+N+ for the MNS framework.

Significance of Blood Groups

Underlying injuries of red platelet 

Of the 33 blood bunch framework antigens, five are characterized by their carb structures (ABO, H, P1Pk, I, GLOB); two are gotten from the plasma (LE, CH⁄RG). The leftover 23 are described by the protein grouping of the RBC film protein, five significant proteins (DI, Rh, RhAG, MNS, GE, and CO) among them are communicated at more significant levels and capability as film carriers, while the practical significance of rest of 17 antigens is obscure. The proposed capability of different antigens is for the most part receptor/ligand flagging, enzymatic action, and glycocalyx arrangement. The invalid aggregate of the framework, be that as it may, shows no invulnerable framework anomalies when contrasted and mice with the exception of a dulled neutrophil reaction on openness to bacterial lipopolysaccharide. Essentially, Knops blood bunch antigen has been related with supplement receptor 1 and Cromer framework with rot speed increase factor. In any case, the clinical
the capability of the invalid aggregates of these blood gatherings still needs to be explained.

Blood Groups and Disease Association

The ABO blood bunches have a significant impact on hemostasis. They apply major quantitative impacts on plasma levels of von Willebrand endlessly factor VIII. An expanded relationship of myocardial localized necrosis, ischemic stroke, and venous thromboembolism is seen with blood bunches A furthermore, AB conceivably through practical ABO glycol transferase tweak apoplexy. A higher gamble of cerebral venous apoplexy has been accounted for in non-O gatherings. A critical relationship of ABO bunches with the pervasiveness of toxemia has been revealed, where AB bunch was viewed as related with an expanded gamble of 2.1-folds. Primer investigations proposed a relationship between the ABO framework with malignancies. A positive relationship has been shown between blood bunch A with ongoing hepatitis-B contamination and pancreatic disease; and blood bunch B with ovarian disease. Insurance against falciparum jungle fever can be accomplished with bunch O by decreasing rosette development. Blood bunch O expands the seriousness of contamination in Vibrio cholerae strains (O1 El Pinnacle and O139).

Blood order After the choice to bond, blood is taken the following step ought to be to arrange a demand during which the following advances should be recalled.

Blood Grouping and Matching

Blood gathering and cross coordinating The most lethal of all bonding-related responses is ABO contradiction causing supplement interceded intravascular hemolysis. Thus, right blood gathering and composing, and cross-checking with the blood demand structure are of most extreme significance. ABO composing is done by testing RBCs for the An and B antigens and the serum for the An and B antibodies prior to bonding. The subsequent stage includes Rh composing with just 15% of the populace being Rh-negative.


Cross-coordinating includes blending of benefactor RBCs with the beneficiary serum to distinguish lethal responses. It has three stages in which the primary stage (1-5 min) includes recognition of ABO incongruence and identification of counter-acting agent against MN, P, and Lewis frameworks. The second stage (30-45 min in egg whites and 10-20 min in low ionic salt arrangement) includes hatching of first stage reactants at 37°C for recognition of deficient antibodies of Rh framework. The third stage comprises the expansion of antiglobulin sera to the hatched second stage reactants to distinguish deficient antibodies of Rh, Kidd, Kell, and Duffy. Among the three stages, the first two stages are more significant as they distinguish those engaged with deadly HTR. The complete time taken for all the three stages in the middle of somewhere in the range of 45 and 60 min.

Antibody Screening 

Here, financially pre-arranged RBCs with all the antigens, which direct the creation of antibodies causing hemolytic responses, are blended in with the beneficiary’s serum to distinguish the presence of those very antibodies. It is likewise completed with the giver’s serum.

Changing practices in Blood Grouping

There are debates with respect to the best strategy for the obtainment of blood during elective and crisis circumstances: (a) It should be possible by regularly requesting gathering and cross-matching in elective careful patients. Numerous logical articles questioned the importance of a preoperative plan of blood in medical procedures where blood misfortune isn’t expected to be huge. (b) Blood might be requested without a full arrangement of examinations. ABO-Rh composing alone brings about a 99.8% opportunity of a viable bonding. Immune response screening builds this wellbeing edge up to 99.94%, and an extra cross-match further expands the similarity to 99.95%. Without cross-coordinating, there is plausible of missing the antigens on benefactor cells, yet in clinical practice, they are of less significance. Consequently, “screening and composing” alone ought to be completed. Different techniques incorporate “type and fractional cross-match,” which incorporates the prompt period of cross-match; “type and uncross match,” for those beneficiaries who have never been bonded previously, the opportunity of recognition of immune response with each cross-match is 1:1000; “type O Rh-negative uncross match,” it is acted in crisis circumstance at the point when the ideal opportunity for these strategies is restricted. In the last option condition, type O Rh-negative stuffed RBCs, that is, the all-inclusive contributor can be utilized as they will have an insignificant measure of the hemolytic enemy of A/hostile to B antibodies against the beneficiary RBCs.

Conceptual Questions

Question 1: What are the important two systems in blood grouping? 


The 2 significant characterizations of blood are the ABO framework and the Rh framework. The 4 blood bunches are A, B, AB, and O. Every one of these will be either Rh-positive or Rh-negative.

Question 2: Who discovered blood groups?


Karl Landsteiner discovered the ABO blood group system. He is an Austrian scientist. It was discovered in 1900.

Question 3: What is the process of transfer of human blood known as?


Blood bonding is the method involved with getting blood or blood items into one’s dissemination intravenously. It is utilized in different ailments to supplant the lost part of blood.

Question 4: Which of the following blood group is referred to as a universal recipient?


Blood bunch AB alludes to a general beneficiary. They can get given blood of any ABO blood bunch.

Question 5: Which blood group is referred to as a universal recipient?


Blood group AB is referred to as a universal recipient. They can receive donated blood from any ABO blood group.

Question 6: Which blood type can be transfused to the individual whose blood type is unknown?


O negative blood type can be transfused to individuals whose blood type is unknown since it is a universal donor blood group. Only6.6% of the population has O negative blood group.

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