Proteins are large and complex biomolecules made up of long chains of amino acid residues that play a crucial role in cells. They are essential in our day-to-day life for good health and benefit in growing something faster. Proteins are made up of smaller units called amino acids. The protein consists of hydrogen, carbon, oxygen, sulfur, and nitrogen.
Table of Content
What is Protein?
Proteins are very complex molecules involved in some chemical processes that are important for life. Protein is made of small units of amino acids. These proteins help in metabolism, communication, and movement in our body.
Also Read: Difference Between Globular and Fibrous Protein
Protein Structure Hierarchy
There are four levels in the structural hierarchy of proteins. They are:
Primary Structure of Protein
In the primary structure of proteins, the polypeptide chain are linked together to form a sequence of amino acids called polypeptide chain. The primary structure of this level contains mainly amino acids which are present in the chain. Peptide bonds are present in the primary structure of the protein.
The primary structure of protein is important as it determines the final fold and hence the function of the protein. Any change in the sequence of amino acids completely changes the entire protein.
If two amino acids are there to form a chain of proteins it is called a dipeptide bond. Similarly, if three amino acids are ready to form a link it is called tripeptide.
Characteristics of peptide bond:
- A peptide bond is rigid and planar
- It is not able to charge but it is polar.
- It has a partial double bond character.
Secondary Structure of Protein
This secondary structure of proteins contains a folding structure polypeptide chain. The secondary structure is formed by the H-bonds. It is formed mostly with the alpha helix and beta pleated sheets. Example: Myoglobin.
There are some types of secondary structure
- Alpha Helix
- Beta plated sheet
- Strand
- Loops
Tertiary Structure of Protein
The tertiary structure of proteins is in the form of a 3-dimentional structure of the monomeric and multimeric structures. This 3D structure of a polypeptide is simply called the tertiary structure of the protein. This tertiary structure is because of the lowest energy and greatest stability state of the polypeptide chain. The structure came from folding secondary structure of the protein.
Function of tertiary structure is that it has a unique function like interacting with other molecules.
Quaternary Structure
The quaternary structure of proteins is in the form of a 3-Dimensional structure of macromolecules which is a combination of individual polypeptide chains. This quaternary structure is also formed from a special combination of tertiary structures. Quaternary structure is also known as oligomeric proteins. Example: Hemoglobin
Functions of quaternary structure:
- It helps in the chromosome replication process.
- It helps in metabolism
Also Read: Protein Structure
Importance of Protein
- Protein helps in maintaining good shape and fit for our body.
- Protein repairs the body’s damaged tissues.
- Protein is used to build bones, skin, and muscles.
Classification of Protein
Classification of proteins is based on the
- Based on the shape
- Based on Constitution
- Based on the Nature of molecules
Based on shape
- Fibrous protein
- Globular proteins
Based on the constitution
- Simple proteins
- Conjugated proteins
Based on nature of molecules
- Acidic proteins: They exist as anion and contain acidic amino acids. Example of acidic protein is Alpha-synuclein.
- Basic proteins: They exist as cations and are rich in basic amino acids. Example of acidic protein are lysine, arginine etc.
The Basic Unit of Protein – Amino Acids:
Amino acids are the basic structural unit of protein. Amino acids consist of the carbon atom, a carboxyl group (COOH), and a hydrogen atom.
Amino acids are classified as follows:
- Aromatic: Tyrosine, Tryptophan, Phenylalanine.
- Positively charged: Lysine, Arginine, Histidine.
- Negatively charged: Aspartate, Glutamate.
- Nonpolar, aliphatic: Leucine, Methionine, Isoleucine.
Function of Protein
Enzymatic protein
The function of enzymatic protein:
- It accelerates the metabolic process in our cells.
- It also accelerates the metabolic process in stomach digestion, liver functions, and blood clotting.
Hormonal protein
The function of hormonal protein
- Hormonal proteins are protein-based chemicals secreted by endocrine glands.
- By using hormonal protein each hormone affects particular cells in the body.
Structural protein
The function of structural protein
- Structural proteins are very important for the body because they are fibrous proteins.
- It helps in developing muscles, bones, skin, and cartilage.
Defensive protein
The function of defensive protein
- These defensive proteins help in developing antibodies for attacking.
- These antibodies are developed in white blood cells to attack bacteria.
Storage protein
The function of storage protein
- Storage protein stores minerals like potassium.
- Storage protein contains ovalbumin and casein found in milk, and egg whites.
Transport protein
The function of transport protein
- Transport protein called calbindin which is useful for absorption of calcium from intestinal walls.
- Transport proteins carry important materials to the cells of the body.
Receptor protein
The function of receptor protein
- It controls the substances which enter and leave the cells.
Contractile protein
The function of contractile protein
- It helps in regulating the strength, speed of the heart, and muscle contractions.
- Contractile proteins cause heart complications if the heart produces severe contractions.
Conclusion – Proteins
Proteins are complex biomolecules which are the building blocks of living organisms. The protein consist of amino acids. The proteins are classified on: basis of shape, constitution, and nature of molecule. The protein structure has hierarchy of four levels i.e. primary structure, secondary structure, tertiary and quaternary structure.
FAQ’s – Proteins
What are Proteins and their Function?
Proteins are large, complex biomolecules made up of long chains of amino acid residues that carry out most important functions in the cell. Proteins help in repairing and building body’s tissues. They serve as structural support, biochemical catalysts, hormones, enzymes, building blocks, and initiators of cellular death.
Why is Protein Structure Important?
The structure of protein is important the shape of protein determines its function and properties. The shape also determines if it will be able to interact with other molecules.
Who Discovered Protein? In Which Year Protein is Discovered?
Gerardus Johannes Mulder who is a Dutch scientist discovered the protein and the name were given by Swedish chemist Jons Jacob Berzelius in 1838.
What Food is Protein?
Food item Protein percentage Egg
12.6
Fish
13-20
Full Chicken
29
Milk
3.5
Leafy vegetables
3
How Much Protein the Human Body Needs Every Day?
Protein is very important for the body of humans. On average, the human body needs approximately 0.8 grams to process its functions.
How Many Groups of Amino Acids Leads to Protein?
Protein is made of a combination of some group of amino acids. If the combination of 20 amino acids gives a protein.
What are 4 Protein Deficiency Diseases?
Disorders caused by the deficiency of proteins are – Kwashiorko, Maramu, Weakness of immune system and Impaired mental health