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Why Thymine is present in DNA instead of Uracil ?

Last Updated : 12 Jan, 2024
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DNA is a micromolecule that consists of many subunits it’s connected together. Those subunits knew as nucleotides. The DNA provides replication and information storage. DNA is described as deoxyribonucleic acid generally it is a polymer of deoxyribonucleotides it’s found in chromosomes, mitochondria chloroplast. It has a double-stranded structure and it acts as genetic material in most organisms they carry the genetic information from one generation to another generation. In 1953, James Watson and Francis crick described as DNA a double helix structure. 

DNA 

DNA is a double-stranded molecule. It is a polymer of nucleotides. It has a deoxyribonucleic acid, phosphate, and 4 different base molecules. Phosphate act as the backbone.

Functions of DNA

  • Replication-transfer the information from one generation to other.
  • Recombination leads to mutation which helps in the evolution
  • Immunological 
  • Gene expansion 
  • Genetics 

Why Thymine is present in DNA instead of Uracil?

Structure of DNA

Structure of DNA

Point 1

  • Thymine is made from uracil in a methylation cycle. The methylation process is the expansion of a methyl bunch(CH3) to a molecule.
  • Methylation is completed by DNA methyltransferase. Most methylated nucleotides are in the coding district of DNA minimal in the advertiser area.
  • Becoming methylated makes the DNA “imperceptible” to nucleases (compounds that separate DNA and RNA). Infections, microbes, and different intruders can’t obliterate the DNA utilizing the nucleases, assuming that DNA is methylated.

Point 2

Particularity in Base Matching

Uracil has more base pair liking to adenine, however, it can likewise match up with different bases including itself. This can prompt changes in our hereditary material. In the event that uracil is utilized as a corresponding base, it very well may be changed during DNA replication and consequently can code for various amino acids and might be for a non-useful protein. By attaching it down to a solitary conformity, the methyl bunch limits uracil (thymine) to matching just with adenine. This incredibly works on the proficiency of DNA replication, by lessening the pace of confounds, and accordingly changes.

Point 3 

Cytosine Deamination

Cytosine can deaminate to create uracil, the main distinction between them is O in uracil and a NH2 in cytosine. That’s what the issue is, assuming uracil were a part of DNA, the maintenance frameworks wouldn’t have the option to recognize unique uracil from uracil began by deamination of cytosine. So utilizing thymine rather makes it way simpler and more steady, as any uracil inside DNA should come from a cytosine thus it tends to be supplanted by another cytosine.

Point 4

Bright light reasons thymine dimers together in DNA, thusly on the off chance that uracil was available in DNA, these uracil dimers wouldn’t be perceived by nucleotide extraction fix.

Why is Thymine Present in DNA?

  1. Thymine has a high resistance to photochemical mutation.
  2. It makes genetic code more durable. 
  3. It has great resistance.

Due to the high resistance of thymine, it is present in the DNA because DNA is transferred from generation to generation any  mismatching leads to mutation which nigh be lethal

FAQs on Why thymine is present in DNA instead of Uracil?

Question 1: Why does thymine make DNA more stable?

Answer:

Thymine has high resistance to photochemical mutation and it makes the genetic messages more stable. 

Question 2: Which cell organism has DNA?

Answer:

DNA-containing organisms called as called eukaryotes.

Question 3: What DNA means?

DNA stands for Deoxyribonucleic Acid it’s the genetic material. 

Question 4: How does information transfer from DNA?

Answer:

DNA transfers information through 3 processes:

  • DNA Replication
  • Transcription
  • Translation

Question 5: IUPAC name of Thymine is?

Answer:

Thymine IUPAC name is  5-methyl-1H-pyrimidine-2,4-dione


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